HbA1c and retinal sensitivity in diabetics using microperimetry / HbA1c y sensibilidad de la retina medida mediante microperimetría en pacientes diabéticos

Purpose: The purpose of this study was to determine the relationship between HbA1c values and retinal sensitivity at central 10° using the MP-1 microperimeter. Methods: A prospective study was carried out on 32 healthy subjects (control group) and 60 diabetic patients. The diabetic patients were divided into 2 groups. Group 1 comprised of 30 patients without diabetic retinopathy (DR) and group 2 had 30 patients with mild non-proliferative DR. A full-threshold microperimetry of the central 10° of retina (the macula) was performed on all subjects, utilizing 32 points with the MP-1. The relationship between light sensitivity and HbA1c value was calculated using linear regression analysis. Results: Total mean sensitivity at 10° for group 1 without DR, group 2 with mild NPDR and control group were 18.67±0.83, 17.98±1.42 and 19.45±0.34 (dB), respectively. There was a significant difference in total mean retinal sensitivity at 10° between the 3 groups (F(2,89)=18.14, p=0.001). A simple linear regression was calculated to predict HbA1c based on retinal sensitivity. A significant regression equation was found (F(1,90)=107.61, p=0.0001, with an R2 of 0.545). The linear regression analysis revealed that there was a 0.64dB decline in mean retinal sensitivity within the central 10° diameter with an increase of 1mmHg of HbA1c. Conclusion: Retinal sensitivity at the central 10° of the macula is affected by changes in HbA1c values

Objetivo: El objetivo de este estudio fue determinar la relación entre los valores de HbA1c y la sensibilidad de la retina en los 10 grados centrales de la misma utilizando el microperímetro MP-1. Métodos: Se realizó un estudio prospectivo en 32 sujetos sanos (grupo control) y 60 pacientes diabéticos. Los pacientes diabéticos se dividieron en dos grupos: el grupo 1 se compuso de 30 pacientes sin retinopatía diabética (RD), y el grupo 2 incluyó a 30 pacientes con RD no proliferativa leve. Se realizó una microperimetría umbral total de los 10° centrales de la retina (la mácula) a todos los sujetos, utilizando 32 puntos con el MP-1. Se calculó la relación entre la sensibilidad retiniana y el valor de HbA1c utilizando un análisis de regresión lineal. Resultados: La sensibilidad media total a los 10° para el grupo 1 sin RD, el grupo 2 con NPDR leve y el grupo control fue de 18,67 ± 0,83, 17,98 ± 1,42 y 19,45 ± 0,34 (dB), respectivamente. Se observó una diferencia significativa en cuanto a sensibilidad media total de la retina a 10° entre los tres grupos (F(2,89) = 18,14, p = 0,001). Se realizó un análisis de regresión lineal simple para predecir HbA1c en base a la sensibilidad de la retina. Se encontró una ecuación de regresión significativa (F(1,9) = 107,61, p = 0,0001, con R2 de 0,545). El análisis de regresión lineal reveló que existe un descenso de 0,64dB de la sensibilidad media de la retina dentro del diámetro de 10° centrales con un incremento de 1 mmHg de HbA1c. Conclusión: La sensibilidad de la retina en los 10 grados centrales de la mácula se ve afectada por los cambios de los valores de HbA1c

HbA1c and retinal sensitivity in diabetics using microperimetry.

PURPOSE: The purpose of this study was to determine the relationship between HbA1c values and retinal sensitivity at central 10° using the MP-1 microperimeter. METHODS: A prospective study was carried out on 32 healthy subjects (control group) and 60 diabetic patients. The diabetic patients were divided into 2 groups. Group 1 comprised of 30 patients without diabetic retinopathy (DR) and group 2 had 30 patients with mild non-proliferative DR. A full-threshold microperimetry of the central 10° of retina (the macula) was performed on all subjects, utilizing 32 points with the MP-1. The relationship between light sensitivity and HbA1c value was calculated using linear regression analysis. RESULTS: Total mean sensitivity at 10° for group 1 without DR, group 2 with mild NPDR and control group were 18.67±0.83, 17.98±1.42 and 19.45±0.34 (dB), respectively. There was a significant difference in total mean retinal sensitivity at 10° between the 3 groups (F(2,89)=18.14, p=0.001). A simple linear regression was calculated to predict HbA1c based on retinal sensitivity. A significant regression equation was found (F(1,90)=107.61, p=0.0001, with an R2 of 0.545). The linear regression analysis revealed that there was a 0.64dB decline in mean retinal sensitivity within the central 10° diameter with an increase of 1mmHg of HbA1c. CONCLUSION: Retinal sensitivity at the central 10° of the macula is affected by changes in HbA1c values.

Macular retinal sensitivity using MP-1 in healthy Malaysian subjects of different ages / Sensibilidad macular retiniana utilizando el microperímetro MP-1 en sujetos sanos Malayos de diferentes edades

Purpose: To determine the influence of age and gender on macular sensitivity to light in healthy subjects of 4 age groups using the MP-1 microperimeter. Methods: A prospective study was carried out on 50 healthy subjects (age range: 18-60 years) divided into 4 age groups; 18-30 years, 31-40 years, 41-50 years and 51-60 years. Full-threshold microperimetry of the central 10° of retina was performed utilizing 32 points with the MP-1. Macula area was divided into four quadrants, which were superior nasal (SN), inferior nasal (IN), inferior temporal (IT) and superior temporal (ST). Results: Total mean sensitivity at 10° for age groups 18-30 years, 31-40 years, 41-50 years and 51–60 years were 19.46±0.30, 19.40±0.39, 19.47±0.35 and 18.73±0.75 (dB), respectively. There was a significant difference in total mean retinal sensitivity at 10° and at the four quadrants with age but not for gender. The retinal sensitivity was highest in the IT quadrant and lowest in the SN quadrant for all age groups. The linear regression analysis revealed that there was a 0.019dB, 0.016dB, 0.022dB, 0.029dB and 0.029dB per year age-related decline in mean macular sensitivity within the central 10° diameter in the SN, IN, IT and ST quadrants respectively. Conclusion: Among normal healthy subjects, there was a linear decline in retinal light sensitivity with increasing age with the highest reduction in the superior nasal quadrant and lowest in the inferior temporal quadrant (AU)

Objetivo: Determinar la influencia de la edad y el sexo en la sensibilidad macular a la luz en sujetos sanos de cuatro grupos de edad, utilizando el microperímetro MP-1. Métodos: Se llevó a cabo un estudio prospectivo en 50 sujetos sanos (rango de edad: 18-60 años), divididos en cuatro grupos de edad; 18-30 años, 31-40 años, 41-50 años y 51-60 años. Se realizó una microperimetría de umbral completo de los 10° centrales de la retina, utilizando 32 puntos con el sistema MP-1. El área macular se dividió en cuatro cuadrantes: superior nasal (SN), inferior nasal (IN), inferior temporal (IT) y superior temporal (ST). Resultados: La sensibilidad media total a los 10° para los grupos de edad de 18-30 años, 31-40 años, 41-50 años y 51-60 años fue de 19,46±0,30, 19,40±0,39, 19,47±0,35 y 18,73±0,75 (dB) respectivamente. Se produjo una diferencia significativa de la sensibilidad retiniana media total a los 10°, y en los cuatro cuadrantes, asociada a la edad pero no al sexo. La sensibilidad retiniana fue superior en el cuadrante IT y menor en el SN en todos los grupos de edad. El análisis de la regresión lineal reveló una disminución anual asociada a la edad de la sensibilidad macular media de 0,019dB, 0,016dB, 0,022dB, 0,029dB y 0,029dB dentro del diámetro central de 10° en los cuadrantes SN, IN, IT y ST respectivamente. Conclusión: Entre los sujetos sanos normales, se produjo una disminución lineal de la sensibilidad retiniana a la luz al incrementar la edad, produciéndose la mayor reducción en el cuadrante superior nasal y la menor en el cuadrante inferior temporal (AU)

Macular retinal sensitivity using MP-1 in healthy Malaysian subjects of different ages.

PURPOSE: To determine the influence of age and gender on macular sensitivity to light in healthy subjects of 4 age groups using the MP-1 microperimeter. METHODS: A prospective study was carried out on 50 healthy subjects (age range: 18-60 years) divided into 4 age groups; 18-30 years, 31-40 years, 41-50 years and 51-60 years. Full-threshold microperimetry of the central 10° of retina was performed utilizing 32 points with the MP-1. Macula area was divided into four quadrants, which were superior nasal (SN), inferior nasal (IN), inferior temporal (IT) and superior temporal (ST). RESULTS: Total mean sensitivity at 10° for age groups 18-30 years, 31-40 years, 41-50 years and 51-60 years were 19.46 ± 0.30, 19.40 ± 0.39, 19.47 ± 0.35 and 18.73 ± 0.75 (dB), respectively. There was a significant difference in total mean retinal sensitivity at 10° and at the four quadrants with age but not for gender. The retinal sensitivity was highest in the IT quadrant and lowest in the SN quadrant for all age groups. The linear regression analysis revealed that there was a 0.019 dB, 0.016 dB, 0.022 dB, 0.029 dB and 0.029 dB per year age-related decline in mean macular sensitivity within the central 10° diameter in the SN, IN, IT and ST quadrants respectively. CONCLUSION: Among normal healthy subjects, there was a linear decline in retinal light sensitivity with increasing age with the highest reduction in the superior nasal quadrant and lowest in the inferior temporal quadrant.